The Thangka depicts:
Guru Rinpoche (Padmasambhava), with Mandarava and Yeshe Tsogyal
Above Guru Rinpoche is Buddha Amitabha.
Below Guru Rinpoche are Dzogchen Masters Longchenpa and Jigme Lingpa.
On the Altar, surrounding Buddha Shakyamuni, are photos of (from left to right):
Back row:
HH Dilgo Khyentse Rinpoche
HH the 16th Karmapa
HH Dudjom Rinpoche
HE Kalu Rinpoche
Front row:
Tulku Urgyen Rinpoche
HH the 17th Karmapa
HH the 14th Dalai Lama
Nyoshul Khenpo Rinpoche